Androgen Insensitivity Syndrome

Androgen insensitivity syndrome (PAIS) is genetic condition that affects the sexual development of a male fetus. During pregnancy, male fetuses with PAIS are unable to properly respond to male sex hormones (androgens). As a result, this affects the development of the genitals. The appearance of the genitals may vary from person to person. Some males have an unusually small penis (microphallus), undescended testes, hypospadias (urethra located on the underside of the penis), and/ or bifid scrotum (scrotum split in two).