An Introduction to IVF with PGT

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In vitro fertilization (IVF) with preimplantation genetic testing (PGT) is a family planning option used to identify genetic or chromosomal differences in embryos before implantation. IVF is a process by which eggs are retrieved from a woman, fertilized by sperm in the lab to create embryos, and then embryos are transferred back into the woman to create a pregnancy. IVF is a prerequisite for PGT.

PGT-M and PGT-A are two types of PGT. PGT-A tests embryos for aneuploidy (abnormal number of chromosomes) and can determine the sex of the embryo. PGT-M tests embryos for single gene conditions including X-linked conditions. PGT-M occurs after the egg is fertilized and the embryo is created but before it is implanted. It is important to note that PGT-M is only possible when the parent(s) specific mutation is known.

All types of PGT are screening tests and therefore not 100% accurate; additionally PGT-M can be a lengthy process that takes several months to complete. Also, there are risks and complications associated with IVF itself. In the United States, IVF generally costs at least $10,000-$20,000 per cycle (not including PGT) and most insurance plans do not cover this. PGT is also not typically covered by insurance, and for single gene disorders (PGT-M) can range from $6,000-$12,000. Additional costs to consider are pre-cycle screening fees ($2,500-$6,000) and IVF medications ($4,000-8,000). In countries with nationalized healthcare, such as the United Kingdom, IVF with PGT may be covered.

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This project is sponsored by Myriad Genetics.

Master List

Check out our X-linked condition master list.

To date, there have been hundreds of X-linked conditions identified—many of them only affecting a few people around the world. While all X-linked conditions are caused by mutations on the X chromosome, each condition is different and has a unique set of symptoms.

Genetic Counselor

Find a genetic counselor for additional advice.

Genetic counselors are healthcare professionals who help individuals and families understand how genetic information impacts their lives. A genetic counselor can provide the most relevant information about each family planning option and answer your questions.

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Connect with others like you in our Facebook support group.

Remember The Girls runs a private Facebook group with over 1,300 members impacted by more than 40 X-linked conditions and from more than 30 countries in the world. Join our online community of females impacted by X-linked conditions to seek and provide support, ask questions, find resources, and learn how to advocate.